After that skill slipped away, I would stand there helplessly on the edge of the neighborhood while remembering that I used to know the way. “Before I lost my ability to problem solve, I could see in my mind’s eye many ways to get from one side of the neighborhood. When considering a legal issue, it was like I was standing at the edge of a vast city neighborhood that I used to know like the back of my hand. And my reading speed slowed even more and I noticed that I was transposing not only letters but also words…. Then, I started mixing up 3s with 8s and Es with Is when typing or using a calculator. In my 20s, I started 'losing the nouns' although I could describe the thing I could not name. “I'm not saying it's the only factor leading to age-related dementia, but it could definitely be one of them.” “The number one cell affected by ageing is the T-cell,” says Kipnis. Sluggish immune cells might also explain why our brains slow down as we age. For example, many chemotherapy drugs suppress the immune system, which might explain why some people with cancer develop “chemobrain” - a term used to describe the cognitive problems and memory loss associated with chemotherapy.
9) Whether these animal studies are relevant to human learning and memory remains unclear, but there is some indirect evidence to support it. Here, they release IL-4, which both switches off the stress response and tells brain cells called astrocytes to release brain-derived neurotrophic factor, a protein that enhances learning. Further animal studies by Kipnis and others show that learning new tasks triggers a mild stress response within the brain, which prompts CD4 cells to rally to the meninges, the membranes that surround the brain. 8) Similarly, when he killed CD4 cells in healthy mice, their memory declined. They found the mice performed extremely poorly in tasks involving learning and memory, but when they were injected with CD4 cells from healthy mice, their memories improved. As described in New Scientist, prompted by studies suggesting immune responses can help repair the nervous system, Jonathan Kipnis and colleagues at the University of Virginia created mice that lack CD4 cells, a kind of T-cell. 5) 6) Management of symptomsĪging immune cells in animal models – The decline in brain function associated with disease and old age could be due to the decline in the function of immune cells, which is likely caused by infection. Some studies seem to suggest that sick women experience cognitive dysfunction more frequently and more severely than their male counterparts. Cognitive dysfunction can be managed using the generic strategies for managing immunopathology, and should resolve over the course of the Marshall Protocol (MP). Like all symptoms of inflammatory disease, cognitive dysfunction may temporarily increase during periods of immunopathology. Often associated with chronic fatigue syndrome, 1) cognitive dysfunction is also seen in patients with multiple sclerosis, 2) depression, 3) fibromyalgia, 4) and dozens of others diseases. More severe forms of cognitive dysfunction are seen in diseases such as Alzheimer's, diseases for which there is strong evidence of a bacterial etiology. Patients with cognitive dysfunction have trouble with verbal recall, basic arithmetic, and concentration.Īccording to the Marshall Pathogenesis, cognitive dysfunction is caused by microbes. Evidence that chronic disease is caused by pathogensĬognitive dysfunction (also known as brain fog) is the loss of intellectual functions such as thinking, remembering, and reasoning of sufficient severity to interfere with daily functioning.Transmission of bacteria and onset of chronic disease.Th1 Spectrum Disorder - how chronic inflammatory diseases are related.
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